発表論文

  1. T. Akagi, and T. Ichiki, “Characterization of EVs by on-chip Immunoelectrophoresis”, Methods in Molecular Biology, Extracellular Vesicles: Methods and Protocols, pp. 209-217 (2017).
  2. H. Takehara, A. Nagaoka, J. Noguchi, T. Akagi, H. Kasai, and T. Ichiki, “Implantable microfluidic device with hydrogel permeable membrane for delivering chemical compounds and imaging neural cells in living mice”, J. Photopolymer Sci. Technol., Vol. 29, No. 4, pp. 513-518 (2016).
    doi: 10.2494/photopolymer.29.513
  3. A. Nagaoka, H. Takehara, A. Hayashi-Takagi, J. Noguchi, K. Ishii, F. Shirai, S. Yagishita, T. Akagi, T. Ichiki and H. Kasai, “Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo”, Sci. Rep., Vol. 6, 26651 (2016).
    doi: 10.1038/srep26651
  4. M. Kojima, H. Takehara, T. Akagi, H. Shiono, T. Ichiki, “Flexible Sheet-Type Sensor for Noninvasive Measurement of Cellular Oxygen Metabolism on a Culture Dish” PLoS ONE, Vol. 10, No. 12, e0143774 (2015).
    doi: 10.1371/journal.pone.0143774
  5. T. Akagi, K. Kato, M. Kobayashi, N. Kosaka, T. Ochiya, and T. Ichiki, “On-Chip Immunoelectrophoresis of Extracellular Vesicles Released from Human Breast Cancer Cells”, PLoS ONE, Vol. 10, No. 4, e0123603 (2015).
    doi: 10.1371/journal.pone.0123603
  6. T. Akagi, N. Hanamura and T. Ichiki, “Measurement of Individual Nanobioparticles on Microfluidic Chips by Laser Dark-field Imaging”, J. Photopolymer Sci. Technol., Vol. 28, No. 5, pp. 727-730 (2015).
    doi: 10.2494/photopolymer.28.727
  7. T. Akagi, R. Kubota, M. Kobayashi, and T. Ichiki, “Development of a polymer-based easy-to-fabricate micro-free-flow electrophoresis devices”, Jpn. J. Appl. Phys., Vol. 54, No. 6S1, 06FN05 (2015).
    doi: 10.7567/JJAP.54.06FN05
  8. S. Ueno, T. Hirai, S. Sato, M. Biyani, H. Kuramochi, R. Iizuka, T. Akagi, T. Funatsu, and T. Ichiki, “In situ synthesis and immobilization of enzyme molecules on microreactor array chips”, J. Photopolymer Sci. Technol., Vol. 5, pp.719 -726 (2015).
    doi: 10.2494/photopolymer.28.719
  9. 一木 隆範, 赤木 貴則,「ナノ医療を加速するナノ粒子解析プラットフォームの開発」, Drug Delivery System, Vol. 30, No. 3, pp.204-211 (2015).
    doi: 10.2745/dds.30.204
  10. 上野 真吾, ビヤニ マニッシュ, 佐藤 秀介, ラジ・クマール スバシニ, 倉持 宏実, 赤木 貴則, 一木 隆範,「高集積マイクロアレイ研究開発の現状と動向」, 分析化学, Vo. 64, No. 6, pp. 42 1-429 (2015).
    doi: 10.2116/bunsekikagaku.64.421
  11. H. Takehara, A. Nagaoka, J. Noguchi, T. Akagi, H. Kasai and T. Ichiki, “Lab-on-a-brain: Implantable micro-optical fluidic devices for neural cell analysis in vivo”, Sci. Rep., Vol. 4, p. 6721 (2014).
    doi: 10.1038/srep06721
  12. T. Akagi, K. Kato, N. Hanamura, M. Kobayashi, and T. Ichiki, “Evaluation of desialylation effect on zeta potential of extracellular vesicles secreted from human prostate cancer cells by on-chip microcapillary electrophoresis”, Jpn. J. Appl. Phys., Vol. 53, No. 6S, 06JL01 (2014).
    doi: 10.7567/JJAP.53.06JL01
  13. T. Ono, R. Iizuka, T. Akagi, T. Funatsu and T. Ichiki, “Optical observation of deep bulk damage in amorphous perfluorocarbon films produced by UV photons emitted from low-pressure argon plasmas”, J. Photopolymer Sci. Technol., Vol. 27, pp. 393-398 (2014).
    doi: 10.2494/photopolymer.27.393
  14. H. Takehara, A. Nagaoka, J. Noguchi, T. Akagi, T. Sakai, U.-I Chung, H. Kasai and T. Ichiki, “Implementation of tetra-poly(ethylene glycol) hydrogel with high mechanical strength into microfluidic device technology”, Biomicrofluidics, Vol. 7, 054109 (2013).
    doi: 10.1063/1.4822033
  15. K. Kato, M. Kobayashi, N. Hanamura, T. Akagi, N. Kosaka, T. Ochiya and T. Ichiki, “Electrokinetic evaluation of individual exosomes by on-chip microcapillary electrophoresis with laser dark-field microscopy”, Jpn. J. Appl. Phys., Vol. 52, No. 6S, p. 06GK10 (2013).
    doi: 10.7567/JJAP.52.06GK10
  16. S. R. Kumal, M. Biyani, S. Ueno, T. Akagi, T. Ichiki, “Simultaneous synthesis and biotinylation of proteins using puromycin-based labeling technology for fabrication of protein array chip”, Jpn. J. Appl. Phys., Vol. 52, No. 6S, pp. 06GK09 (2013).
    doi: 10.7567/JJAP.52.06GK09
  17. K. Kato, M. Koido, M. Kobayashi, T. Akagi, and T. Ichiki, “Statistical fluctuation in zeta potential distribution of nanoliposomes measured by on-chip microcapillary electrophoresis”, Electrophoresis, Vol. 34, No. 8, pp.1212-1208 (2013).
    doi: 10.1002/elps.201370081
  18. T. Ono, R. Iizuka, T. Akagi, T. Funatsu and T. Ichiki, “Damage-free Fabrication of Perfluoropolymer Microaperture Array Device for Single-molecule Imaging”, Trans. Mater. Res. Soc. Jpn. Vol. 36, No. 4, pp.553-556 (2011).
    doi: 10.14723/tmrsj.36.553
  19. 松橋隆太郎, 赤木貴則, 一木隆範, “マイクロチップを用いたHL60細胞の好中球分化に伴う電気泳動度の変化の測定”, 電気学会論文誌E, Vol. 131, No. 2, pp.65-69, (2011).
    doi: 10.1541/ieejsmas.131.65
  20. T. Akagi, Y. Hamada, and T. Ichiki, “Electrophoretic mobility of mouse leukocytes evaluated using microcapillary electrophoresis chips.”, Trans. Mater. Res. Soc. Jpn., Vol. 35, No. 2, pp.259-262 (2010).
    doi: 10.14723/tmrsj.35.259
  21. R. Matsuhashi, T. Akagi, and T. Ichiki, “Measurement of electrophoretic mobility of human mesenchymal stem cells during osteogenic differentiation using microcapillary chips.”, Trans. Mater. Res. Soc. Jpn., Vol. 35, No. 2, pp.263-266 (2010).
    doi: 10.14723/tmrsj.35.263
  22. T. Ono, T. Akagi, and T. Ichiki, “Hydrophilization of amorphous perfluoro- polymer using low-pressure argon plasma.”, J. Photopolymer. Sci. Tech., Vol. 22, pp.683-689 (2009)
    doi: 10.2494/photopolymer.22.683
  23. Y. Hosoi, T. Akagi, and T. Ichiki, “Development of microreactor array chip-based measurement system for massively parallel analysis of enzymatic activity.”, Electronics and Communications in Japan, Vol. 92, No. 4, pp.35-41 (2009).
    doi: 10.1002/ecj.10056
  24. T. Ono, T. Akagi, and T. Ichiki, “Anisotropic etching of amorphous perfluoropolymer films in oxygen-based inductively coupled plasmas”, J. Appl. Phys., Vol. 105, pp.013314 (2009)
    doi: 10.1063/1.3058601
  25. T. Akagi, T. Fukagawa, Y. Kage, H. To, N. Matsunaga, S. Koyanagi, A Uchida, A. Fujii, H. Iba, T. Ikemura, H. Aramaki, S. Higuchi, and S. Ohdo, “Role of glucocorticoid receptor in the regulation of cellular sensitivity to irinotecan hydrochloride” J. Pharmacol. Sci., Vol. 109, No. 2, pp.265-274 (2009) doi: 10.1254/jphs.08219FP
  26. T. Akagi, and T. Ichiki, “Cell electrophoresis on a chip: what can we know from the changes in electrophoretic mobility?”, Anal. Bioanal. Chem., Vol. 391, No. 7, pp.2433-2441 (2008).
    doi: 10.1007/s00216-008-2203-9
  27. T. Akagi, A.Minamino, and T. Ichiki, “Development of Microdevices for Physioelectrical Measurement of Biological Cells.”, Electronics and Communications in Japan, Vol. 91, No. 1, p.40-45 (2008).
    doi: 10.1002/ecj.10027
  28. 一木隆範, 赤木貴則, “チップ型電気泳動による細胞の非侵襲計測” バイオサイエンスとインダストリー, Vol. 66, No. 11, pp.604-609 (2008).
    Link
  29. 平田孝道, 畠山力三, 金子俊郎, 岡田健, 秋谷昌宏, 島谷裕一, 一木隆範, 赤木貴則, 「ナノスコピックプラズマプロセスによるバイオデバイス構築」(解説), プラズマ核融合学会誌 83(8) pp. 647-657 (2007).
    CiNii
  30. T. Akagi, M. Suzuki, S. Sato and T. Ichiki, “On-chip evaluation of damage on cell surfaces induced by cell dissociation agents”, Jpn. J. Appl. Phys., Vol. 46, No. 9B, pp. 6404-6409 (2007).
    doi: 10.1143/JJAP.46.6404
  31. 細居洋介, 赤木貴則, 一木隆範, 「マイクロリアクターアレイチップを用いた酵素機能高効率スクリーニングシステムの開発」, 電気学会論文誌, Vol. 127-C, No. 10, pp. 1508-1514 (2007).
    doi: 10.1541/ieejeiss.127.1508
  32. Y. Hamada, T. Ono, T. Akagi, K. Ishihara, and T. Ichiki, “Photochemical oxidation of poly(dimethylsiloxane) surface and subsequent coating with biomimetic phosphorylcholine polymer”, J. Photopolymer Sci. Tech., Vol. 20, pp. 245-249 (2007).
    doi: 10.1007/s00216-008-2203-9
  33. Helen M. L. Tan, H. Fukuda, T. Akagi and T. Ichiki, “Surface modification of poly(dimethyl-siloxane) for controlling biological cells’ adhesion using a scanning radical microjet”, Thin Solid Films, Vol. 515, pp. 5172-5178 (2007).
    doi: 10.2494/photopolymer.19.245
  34. T. Akagi, M. Suzuki and T. Ichiki, “Application of on-chip cell electrophoresis to evaluation of cell cycle wtages of HL-60 cells”, Jpn. J. Appl. Phys., Vol. 45, pp. L1106-L1109 (2006).
    doi: 10.1143/JJAP.45.L1106
  35. Helen M. L. Tan, T. Akagi, and T. Ichiki, “Localized plasma treatment of poly(dimethylsiloxane) surface and its application to controlled cell cultivation”, J. Photopolymer Sci. and Technol., Vol. 19, pp. 245-250 (2006).
    doi: 10.2494/photopolymer.19.245
  36. 赤木貴則、南野淳、一木隆範、「微細加工技術による細胞電気生理計測デバイスの開発」、電気学会論文誌, Vol. 126-C, pp. 730-735 (2006).
    doi: 10.1541/ieejeiss.126.730
  37. T. Akagi, K. Ushinohama, S. Ikesue, E. Yukawa, S. Higuchi, K. Hamase, K. Zaitsu and S. Ohdo, “Chronopharmacology of melatonin in mice to maximize the antitumor effect and minimize the rhythm disturbance effect”, J. Pharmacol. Exp. Ther., 308, pp.378-384 (2004).
    doi: 10.1124/jpet.103.055657
  38. T. Akagi, K. Ushinohama, Y. Kage, T. Ishizaki, T. Makinosumi, A. Yamauchi, Y. Taguchi, K. Inoue, E. Yukawa, S. Higuchi and S. Ohdo, “Cell kinetics-dependent antitumor effect of irinotecan hydrochloride induced by the synchronizing effect of hydroxyurea: cell kinetics and dosing time”, Life Sci., Vol. 72, pp.1183-1197 (2003).
    doi: 10.1016/S0024-3205(02)02363-9
  39. 牛之濱風見、赤木貴則、大戸茂弘、池末祥子、湯川榮二、樋口駿、「外因性メラトニンの抗腫瘍効果に及ぼす投薬時刻の影響」、臨床薬理、Vol. 33、No. 1、pp. 75-76 (2002).
    doi: 10.3999/jscpt.33.75S
  40. 赤木貴則、大戸茂弘、牛之濱風見、湯川榮二、樋口駿、「塩酸イリノテカンの抗腫瘍効果に及ぼす細胞周期同調剤の影響:細胞動態と併用のタイミング」、臨床薬理、Vol. 31、No. 2、pp. 437-438 (2000).
    doi: 10.3999/jscpt.31.437